Bevacizumab-Induced Alterations in Vascular Permeability and Drug Delivery: A Novel Approach to Augment Regional Chemotherapy for In-Transit Melanoma

PURPOSE: To investigate whether the systemically administered anti-VEGF monoclonal antibody bevacizumab could improve regional chemotherapy treatment of advanced extremity melanoma by enhancing delivery and tumor uptake of regionally infused melphalan (LPAM). EXPERIMENTAL DESIGN: After treatment wit...

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Päätekijät: Turley, Ryan S., Fontanella, Andrew N., Padussis, James C., Toshimitsu, Hiroaki, Tokuhisa, Yoshihiro, Cho, Eugenia H., Hanna, Gabi, Beasley, Georgia M., Augustine, Christina K., Dewhirst, Mark W., Tyler, Douglas S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2012
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3618183/
https://ncbi.nlm.nih.gov/pubmed/22496203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-3000
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