Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56(bright) subset

Mutations in the transcription factor GATA2 underlie the syndrome of monocytopenia and B- and natural killer (NK)-cell lymphopenia associated with opportunistic infections and cancers. In addition, patients have recurrent and severe viral infections. NK cells play a critical role in mediating antivi...

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Autori principali: Mace, Emily M., Hsu, Amy P., Monaco-Shawver, Linda, Makedonas, George, Rosen, Joshua B., Dropulic, Lesia, Cohen, Jeffrey I., Frenkel, Eugene P., Bagwell, John C., Sullivan, John L., Biron, Christine A., Spalding, Christine, Zerbe, Christa S., Uzel, Gulbu, Holland, Steven M., Orange, Jordan S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2013
Soggetti:
Immunobiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617632/
https://ncbi.nlm.nih.gov/pubmed/23365458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-09-453969
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