Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56(bright) subset

Mutations in the transcription factor GATA2 underlie the syndrome of monocytopenia and B- and natural killer (NK)-cell lymphopenia associated with opportunistic infections and cancers. In addition, patients have recurrent and severe viral infections. NK cells play a critical role in mediating antivi...

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Autors principals: Mace, Emily M., Hsu, Amy P., Monaco-Shawver, Linda, Makedonas, George, Rosen, Joshua B., Dropulic, Lesia, Cohen, Jeffrey I., Frenkel, Eugene P., Bagwell, John C., Sullivan, John L., Biron, Christine A., Spalding, Christine, Zerbe, Christa S., Uzel, Gulbu, Holland, Steven M., Orange, Jordan S.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2013
Matèries:
Immunobiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617632/
https://ncbi.nlm.nih.gov/pubmed/23365458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-09-453969
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