A position-dependent silencer plays a major role in repressing alpha-fetoprotein expression in human hepatoma.

A large percentage of human hepatomas produce alpha-fetoprotein (AFP), but the levels of AFP expression vary greatly among hepatomas. To understand the molecular basis for this variation, we analyzed transcriptional regulatory activities associated with the 5'-flanking region of the AFP gene in two...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Nakabayashi, H, Hashimoto, T, Miyao, Y, Tjong, K K, Chan, J, Tamaoki, T
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC361738/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1719374/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.11.12.5885-5893.1991
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