FXR Agonist INT-747 Upregulates DDAH Expression and Enhances Insulin Sensitivity in High-Salt Fed Dahl Rats

AIMS: Genetic and pharmacological studies have shown that impairment of the nitric oxide (NO) synthase (NOS) pathway is associated with hypertension and insulin-resistance (IR). In addition, inhibition of NOS by the endogenous inhibitor, asymmetric dimethylarginine (ADMA), may also result in hyperte...

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Detalhes bibliográficos
Main Authors: Ghebremariam, Yohannes T., Yamada, Keisuke, Lee, Jerry C., Johnson, Christine L. C., Atzler, Dorothee, Anderssohn, Maike, Agrawal, Rani, Higgins, John P., Patterson, Andrew J., Böger, Rainer H., Cooke, John P
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617194/
https://ncbi.nlm.nih.gov/pubmed/23593273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060653
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