3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is the fourth most common cause of cancer related death. It is lethal in nearly all patients, due to an almost complete chemoresistance. Most if not all drugs that pass preclinical tests successfully, fail miserably in the patient. This raises the...

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Detaylı Bibliyografya
Asıl Yazarlar: Longati, Paola, Jia, Xiaohui, Eimer, Johannes, Wagman, Annika, Witt, Michael-Robin, Rehnmark, Stefan, Verbeke, Caroline, Toftgård, Rune, Löhr, Matthias, Heuchel, Rainer L
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2013
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617005/
https://ncbi.nlm.nih.gov/pubmed/23446043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-95
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