3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is the fourth most common cause of cancer related death. It is lethal in nearly all patients, due to an almost complete chemoresistance. Most if not all drugs that pass preclinical tests successfully, fail miserably in the patient. This raises the...

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Detalhes bibliográficos
Main Authors: Longati, Paola, Jia, Xiaohui, Eimer, Johannes, Wagman, Annika, Witt, Michael-Robin, Rehnmark, Stefan, Verbeke, Caroline, Toftgård, Rune, Löhr, Matthias, Heuchel, Rainer L
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617005/
https://ncbi.nlm.nih.gov/pubmed/23446043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-95
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