Allosteric Modulation of the HIV-1 gp120-gp41 Association Site by Adjacent gp120 Variable Region 1 (V1) N-Glycans Linked to Neutralization Sensitivity

The HIV-1 gp120-gp41 complex, which mediates viral fusion and cellular entry, undergoes rapid evolution within its external glycan shield to enable escape from neutralizing antibody (NAb). Understanding how conserved protein determinants retain functionality in the context of such evolution is impor...

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Main Authors: Drummer, Heidi E., Hill, Melissa K., Maerz, Anne L., Wood, Stephanie, Ramsland, Paul A., Mak, Johnson, Poumbourios, Pantelis
格式: Artigo
語言:Inglês
出版: Public Library of Science 2013
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616969/
https://ncbi.nlm.nih.gov/pubmed/23592978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003218
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