Allosteric Modulation of the HIV-1 gp120-gp41 Association Site by Adjacent gp120 Variable Region 1 (V1) N-Glycans Linked to Neutralization Sensitivity

The HIV-1 gp120-gp41 complex, which mediates viral fusion and cellular entry, undergoes rapid evolution within its external glycan shield to enable escape from neutralizing antibody (NAb). Understanding how conserved protein determinants retain functionality in the context of such evolution is impor...

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Autores principales: Drummer, Heidi E., Hill, Melissa K., Maerz, Anne L., Wood, Stephanie, Ramsland, Paul A., Mak, Johnson, Poumbourios, Pantelis
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616969/
https://ncbi.nlm.nih.gov/pubmed/23592978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003218
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