DNA damage signaling induced by the G-quadruplex ligand 12459 is modulated by PPM1D/WIP1 phosphatase

The triazine derivative 12459 is a potent G-quadruplex ligand that triggers apoptosis or delayed growth arrest, telomere shortening and G-overhang degradation, as a function of its concentration and time exposure to the cells. We have investigated here the DNA damage response induced by 12459 in A54...

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Bibliographische Detailangaben
Hauptverfasser: Douarre, Céline, Mergui, Xénia, Sidibe, Assitan, Gomez, Dennis, Alberti, Patrizia, Mailliet, Patrick, Trentesaux, Chantal, Riou, Jean-François
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2013
Schlagworte:
Genome Integrity, Repair and Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616712/
https://ncbi.nlm.nih.gov/pubmed/23396447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt073
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