Chemoprevention of lung tumorigenesis by intranasally administered diindolylmethane in A/J mice

Eitemau Tebyg

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• Lipopolysaccharide enhances mouse lung tumorigenesis: A model for inflammation-driven lung cancer
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• RNA-Sequencing studies identify genes differentially regulated during inflammation-driven lung tumorigenesis and targeted by chemopreventive agents
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• Enhanced inhibition of lung adenocarcinoma by combinatorial treatment with indole-3-carbinol and silibinin in A/J mice
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• Combinations of indole-3-carbinol and silibinin suppress inflammation-driven mouse lung tumorigenesis by modulating critical cell cycle regulators
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  Cyhoeddwyd: (2015)