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Stent elution rate determines drug deposition and receptor-mediated effects

Drug eluting stent designs abound and yet the dependence of efficacy on drug dose and elution duration remains unclear. We examined these issues within a mathematical framework of arterial drug distribution and receptor binding following stent elution. Model predictions that tissue content linearly...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Tzafriri, Abraham R., Groothuis, Adam, Price, G. Sylvester, Edelman, Elazer R.
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616625/
https://ncbi.nlm.nih.gov/pubmed/22642931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2012.05.039
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