Canonical and Atypical E2Fs Regulate the Mammalian Endocycle

The endocycle is a variant cell cycle consisting of successive DNA synthesis and Gap phases that yield highly polyploid cells. Although essential for metazoan development, relatively little is known about its control or physiologic role in mammals. Using novel lineage-specific cre mice we identified...

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Main Authors: Chen, Hui-Zi, Ouseph, Madhu M., Li, Jing, Pécot, Thierry, Chokshi, Veda, Kent, Lindsey, Bae, Sooin, Byrne, Morgan, Duran, Camille, Comstock, Grant, Trikha, Prashant, Mair, Markus, Senapati, Shantibhusan, Martin, Chelsea K., Gandhi, Sagar, Wilson, Nicholas, Liu, Bin, Huang, Yi-Wen, Thompson, John C., Raman, Sundaresan, Singh, Shantanu, Leone, Marcelo, Machiraju, Raghu, Huang, Kun, Mo, Xiaokui, Fernandez, Soledad, Kalaszczynska, Ilona, Wolgemuth, Debra J., Sicinski, Piotr, Huang, Tim, Jin, Victor, Leone, Gustavo
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616487/
https://ncbi.nlm.nih.gov/pubmed/23064266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2595
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