NOVEL SPHINGOSINE-1-PHOSPHATE RECEPTOR MODULATOR KRP203 COMBINED WITH LOCALLY-DELIVERED REGULATORY T-CELLS INDUCES PERMANENT ACCEPTANCE OF PANCREATIC ISLET ALLOGRAFTS

BACKGROUND: KRP203, a structural FTY720 analog, has 5-fold greater selectivity for binding to sphingosine-1-phosphate receptor 1 (S1PR(1)) versus S1PR(3) and 100-fold greater selectivity over S1PR(2) and S1PR(5). Although the immune regulatory effects of FTY720 have been tested in clinical and exper...

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Main Authors: Khattar, Mithun, Deng, Ronghai, Kahan, Barry D, Schroder, Paul M, Phan, Tammy, Rutzky, Lynne P, Stepkowski, Stanislaw M
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616331/
https://ncbi.nlm.nih.gov/pubmed/23545505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0b013e3182842396
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