Genetic Variations in SMAD7 Are Associated with Colorectal Cancer Risk in the Colon Cancer Family Registry

BACKGROUND: Recent genome-wide studies identified a risk locus for colorectal cancer at 18q21, which maps to the SMAD7 gene. Our objective was to confirm the association between SMAD7 SNPs and colorectal cancer risk in the multi-center Colon Cancer Family Registry. MATERIALS AND METHODS: 23 tagging...

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Główni autorzy: Jiang, Xuejuan, Castelao, J. Esteban, Vandenberg, David, Carracedo, Angel, Redondo, Carmen M., Conti, David V., Paredes Cotoré, Jesus P., Potter, John D., Newcomb, Polly A., Passarelli, Michael N., Jenkins, Mark A., Hopper, John L., Gallinger, Steven, Le Marchand, Loic, Martínez, María E., Ahnen, Dennis J., Baron, John A., Lindor, Noralane M., Haile, Robert W., Gago-Dominguez, Manuela
Format: Artigo
Język:Inglês
Wydane: Public Library of Science 2013
Hasła przedmiotowe:
Research Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616155/
https://ncbi.nlm.nih.gov/pubmed/23560096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060464
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