The endoglycosidase heparanase enters the nucleus of T lymphocytes and modulates H3 methylation at actively transcribed genes via the interplay with key chromatin modifying enzymes

The methylation of histones is a fundamental epigenetic process regulating gene expression programs in mammalian cells. Dysregulated patterns of histone methylation are directly implicated in malignant transformation. Here, we report the unexpected finding that the invasive extracellular matrix degr...

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Bibliografski detalji
Glavni autori: He, Yi Qing, Sutcliffe, Elissa L., Bunting, Karen L., Li, Jasmine, Goodall, Katharine J., Poon, Ivan K.A., Hulett, Mark D., Freeman, Craig, Zafar, Anjum, McInnes, Russell L., Taya, Toshiki, Parish, Christopher R., Rao, Sudha
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2012
Teme:
Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616083/
https://ncbi.nlm.nih.gov/pubmed/22771948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/trns.19998
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