The endoglycosidase heparanase enters the nucleus of T lymphocytes and modulates H3 methylation at actively transcribed genes via the interplay with key chromatin modifying enzymes

The methylation of histones is a fundamental epigenetic process regulating gene expression programs in mammalian cells. Dysregulated patterns of histone methylation are directly implicated in malignant transformation. Here, we report the unexpected finding that the invasive extracellular matrix degr...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: He, Yi Qing, Sutcliffe, Elissa L., Bunting, Karen L., Li, Jasmine, Goodall, Katharine J., Poon, Ivan K.A., Hulett, Mark D., Freeman, Craig, Zafar, Anjum, McInnes, Russell L., Taya, Toshiki, Parish, Christopher R., Rao, Sudha
Format: Artigo
Langue:Inglês
Publié: Landes Bioscience 2012
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616083/
https://ncbi.nlm.nih.gov/pubmed/22771948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/trns.19998
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