The endoglycosidase heparanase enters the nucleus of T lymphocytes and modulates H3 methylation at actively transcribed genes via the interplay with key chromatin modifying enzymes

The methylation of histones is a fundamental epigenetic process regulating gene expression programs in mammalian cells. Dysregulated patterns of histone methylation are directly implicated in malignant transformation. Here, we report the unexpected finding that the invasive extracellular matrix degr...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: He, Yi Qing, Sutcliffe, Elissa L., Bunting, Karen L., Li, Jasmine, Goodall, Katharine J., Poon, Ivan K.A., Hulett, Mark D., Freeman, Craig, Zafar, Anjum, McInnes, Russell L., Taya, Toshiki, Parish, Christopher R., Rao, Sudha
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Landes Bioscience 2012
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616083/
https://ncbi.nlm.nih.gov/pubmed/22771948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/trns.19998
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