Secretion of MIP-1β and MIP-1α by CD8(+) T-lymphocytes Correlates with HIV-1 Inhibition Independent of Coreceptor Usage

CD8(+) T-lymphocytes can utilize noncytolytic mechanisms to suppress HIV-1 replication through the secretion of soluble factors. The secretion of MIP-1β, MIP-1α, IP-10, MIG, IL-1α, and interferon gamma correlated most strongly with soluble noncytolytic suppression (p < 0.0001). Since the noncytol...

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Hoofdauteurs: Saunders, Kevin O., Ward-Caviness, Cavin, Schutte, Robert J., Freel, Stephanie A., Overman, R. Glenn, Thielman, Nathan M., Cunningham, Coleen K., Kepler, Thomas B., Tomaras, Georgia D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3615706/
https://ncbi.nlm.nih.gov/pubmed/21030011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellimm.2010.09.011
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