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A High-Content Biosensor Based Screen Identifies Cell Permeable Activators and Inhibitors of EGFR Function: Implications in Drug Discovery

Early success of kinase inhibitors has validated their use as drugs. However, discovery efforts have also suffered from high attrition rates; due to lack of cellular activity. We reasoned that screening for such candidates in live cells would identify novel cell permeable modulators for development....

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Antczak, Christophe, Mahida, Jeni P., Bhinder, Bhavneet, Calder, Paul A., Djaballah, Hakim
פורמט: Artigo
שפה:Inglês
יצא לאור: 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3615554/
https://ncbi.nlm.nih.gov/pubmed/22573732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057112446174
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