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Phosphoinositide 3-Kinase Inhibition in Chronic Lymphocytic Leukemia
Phosphoinositide 3’-kinase (PI3K) is a key node in the B cell receptor (BCR) pathway, which plays a crucial role in the trafficking, survival, and proliferation of chronic lymphocytic leukemia (CLL) cells. We review the biology of the PI3K with a focus on its relationship to the CLL microenvironment...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3615463/ https://ncbi.nlm.nih.gov/pubmed/23561476 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hoc.2012.12.002 |
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