Two distinct alpha-interferon-dependent signal transduction pathways may contribute to activation of transcription of the guanylate-binding protein gene.

The promoter of the gene encoding a cytoplasmic guanylate-binding protein (GBP) contains two overlapping elements: the interferon stimulation response element (ISRE), which mediates alpha interferon (IFN-alpha)-dependent transcription, and the IFN-gamma activation site (GAS), which is required for I...

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Bibliographic Details
Published in:Mol Cell Biol
Main Authors: Decker, T, Lew, D J, Darnell, J E
Format: Artigo
Language:Inglês
Published: Taylor & Francis 1991
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC361534/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1833631/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.11.10.5147
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