Downregulation of Signaling-active IGF-1 by Dipeptidyl Peptidase IV (DPP-IV)

Functioning as an extracellular protease, dipeptidyl peptidase IV (DPP-IV) preferentially cleaves the peptide bond after the penultimate proline residue. We report here that DPP-IV cleaves the first two amino acids from insulin-like growth factor 1 (IGF-1), revealed by mass spectrometry. The kinetic...

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Hlavní autoři: Lin, Ching-Ting, Tang, Hsiang-Yun, Han, Yu-San, Liu, Hui-Ping, Huang, Shiu-Feng, Chien, Chia-Hui, Shyy, John, Chiu, Jeng-Jian, Chen, Xin
Médium: Artigo
Jazyk:Inglês
Vydáno: Master Publishing Group 2010
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3615292/
https://ncbi.nlm.nih.gov/pubmed/23675206
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