The Calpain/Calpastatin System Has Opposing Roles in Growth and Metastatic Dissemination of Melanoma

Conventional calpains are ubiquitous cysteine proteases whose activity is promoted by calcium signaling and specifically limited by calpastatin. Calpain expression has been shown to be increased in human malignant cells, but the contribution of the calpain/calpastatin system in tumorigenesis remains...

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Bibliographic Details
Main Authors: Raimbourg, Quentin, Perez, Joëlle, Vandermeersch, Sophie, Prignon, Aurélie, Hanouna, Guillaume, Haymann, Jean-Philippe, Baud, Laurent, Letavernier, Emmanuel
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3614974/
https://ncbi.nlm.nih.gov/pubmed/23565252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060469
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