Dominant inhibitory mutations in the Mg(2+)-binding site of RasH prevent its activation by GTP.

We have previously demonstrated that substitution of Asn for Ser at position 17 of RasH yields a dominant inhibitory protein whose expression in cells interferes with endogenous Ras function (L. A. Feig, and G. M. Cooper, Mol. Cell. Biol. 8:3235-3243, 1988). Subsequent structural studies have shown...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Farnsworth, C L, Feig, L A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC361448/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1922022/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.11.10.4822-4829.1991
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