Dysfunctional mitochondrial respiration in the striatum of the Huntington’s disease transgenic R6/2 mouse model

Metabolic dysfunction and mitochondrial involvement are recognised as part of the pathology in Huntington's Disease (HD). Post-mortem examinations of the striatum from end-stage HD patients have shown a decrease in the in vitro activity of complexes II, III and IV of the electron transport syst...

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Hlavní autoři: Aidt, Frederik Heurlin, Nielsen, Signe Marie Borch, Kanters, Jørgen, Pesta, Dominik, Nielsen, Troels Tolstrup, Nørremølle, Anne, Hasholt, Lis, Christiansen, Michael, Hagen, Christian Munch
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
Témata:
HD Models
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3614423/
https://ncbi.nlm.nih.gov/pubmed/23568011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/currents.hd.d8917b4862929772c5a2f2a34ef1c201
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