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Alkbh2 protects against lethality and mutation in primary mouse embryonic fibroblasts
Alkylating agents modify DNA and RNA forming adducts that disrupt replication and transcription, trigger cell cycle checkpoints and/or initiate apoptosis. If left unrepaired, some of the damage can be cytotoxic and/or mutagenic. In Escherichia coli, the alkylation repair protein B (AlkB) provides on...
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Main Authors: | , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2012
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3614354/ https://ncbi.nlm.nih.gov/pubmed/22429847 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2012.02.005 |
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