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Alkbh2 protects against lethality and mutation in primary mouse embryonic fibroblasts

Alkylating agents modify DNA and RNA forming adducts that disrupt replication and transcription, trigger cell cycle checkpoints and/or initiate apoptosis. If left unrepaired, some of the damage can be cytotoxic and/or mutagenic. In Escherichia coli, the alkylation repair protein B (AlkB) provides on...

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Detalhes bibliográficos
Main Authors: Nay, Stephanie L., Lee, Dong-Hyun, Bates, Steven E., O’Connor, Timothy R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3614354/
https://ncbi.nlm.nih.gov/pubmed/22429847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2012.02.005
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