Desmoglein-1/Erbin interaction suppresses ERK activation to support epidermal differentiation

Genetic disorders of the Ras/MAPK pathway, termed RASopathies, produce numerous abnormalities, including cutaneous keratodermas. The desmosomal cadherin, desmoglein-1 (DSG1), promotes keratinocyte differentiation by attenuating MAPK/ERK signaling and is linked to striate palmoplantar keratoderma (SP...

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Autors principals: Harmon, Robert M., Simpson, Cory L., Johnson, Jodi L., Koetsier, Jennifer L., Dubash, Adi D., Najor, Nicole A., Sarig, Ofer, Sprecher, Eli, Green, Kathleen J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2013
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3613912/
https://ncbi.nlm.nih.gov/pubmed/23524970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65220
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