Widespread resetting of DNA methylation in glioblastoma-initiating cells suppresses malignant cellular behavior in a lineage-dependent manner

Epigenetic changes are frequently observed in cancer. However, their role in establishing or sustaining the malignant state has been difficult to determine due to the lack of experimental tools that enable resetting of epigenetic abnormalities. To address this, we applied induced pluripotent stem ce...

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Detalhes bibliográficos
Main Authors: Stricker, Stefan H., Feber, Andrew, Engström, Pär G., Carén, Helena, Kurian, Kathreena M., Takashima, Yasuhiro, Watts, Colin, Way, Michael, Dirks, Peter, Bertone, Paul, Smith, Austin, Beck, Stephan, Pollard, Steven M.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2013
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3613612/
https://ncbi.nlm.nih.gov/pubmed/23512659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.212662.112
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