Antifungal properties of the immunosuppressant FK-506: identification of an FK-506-responsive yeast gene distinct from FKB1.

FK-506 is a novel and potent antagonist of T-cell activation and an inhibitor of fungal growth. Its immunosuppressive activity can be antagonized by the structurally related antibiotic rapamycin, and both compounds interact with cytoplasmic FK-506-binding proteins (FKBPs) in T cells and yeast cells....

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Pubblicato in:	Mol Cell Biol
Autori principali:	Brizuela, L, Chrebet, G, Bostian, K A, Parent, S A
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 1991
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC361345/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1715022/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.11.9.4616-4626.1991
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