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Tacrolimus Inhibits NF-κB Activation in Peripheral Human T Cells
The calcineurin inhibitor, tacrolimus (TAC), inhibits the protein phosphatase activity of calcineurin, leading to suppression of the nuclear translocation of NFAT and inhibition of T cell activation. Apart from NFAT also the transcription factor NF-κB plays a key functional role in T cell activation...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3613409/ https://ncbi.nlm.nih.gov/pubmed/23573283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060784 |
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