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Distinct roles for neutrophils and dendritic cells in inflammation and autoimmunity in motheaten mice

The motheaten mouse has long served as a paradigm for complex autoimmune and inflammatory disease. Null mutations in Ptpn6, which encodes the non-receptor protein-tyrosine phosphatase Shp1, cause the motheaten phenotype. However, Shp1 regulates multiple signaling pathways in different hematopoietic...

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Autors principals: Abram, Clare L., Roberge, Gray L., Pao, Lily I., Neel, Benjamin G., Lowell, Clifford A.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3613338/
https://ncbi.nlm.nih.gov/pubmed/23521885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2013.02.018
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