Susceptibility-associated genetic variation at IL12B enhances Th1 polarization in psoriasis

The IL12B gene encodes the common p40 subunit of IL-12 and IL-23, cytokines with key roles in Th1 and Th17 biology, respectively, and genetic variation in this region significantly influences risk of psoriasis. Here, we demonstrate that a psoriasis-associated risk haplotype at the IL12B locus leads...

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Main Authors: Johnston, Andrew, Xing, Xianying, Swindell, William R., Kochkodan, James, Riblett, MaryBeth, Nair, Rajan P., Stuart, Philip E., Ding, Jun, Voorhees, John J., Elder, James T., Gudjonsson, Johann E.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2013
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3613166/
https://ncbi.nlm.nih.gov/pubmed/23376980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt034
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