Protein profiles in Tc1 mice implicate novel pathway perturbations in the Down syndrome brain

Tc1 mouse model of Down syndrome (DS) is functionally trisomic for ∼120 human chromosome 21 (HSA21) classical protein-coding genes. Tc1 mice display features relevant to the DS phenotype, including abnormalities in learning and memory and synaptic plasticity. To determine the molecular basis for the...

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Hlavní autoři: Ahmed, Md. Mahiuddin, Dhanasekaran, A. Ranjitha, Tong, Suhong, Wiseman, Frances K., Fisher, Elizabeth M.C., Tybulewicz, Victor L.J., Gardiner, Katheleen J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3613160/
https://ncbi.nlm.nih.gov/pubmed/23349361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt017
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