Liver cells contain constitutive DNase I-hypersensitive sites at the xenobiotic response elements 1 and 2 (XRE1 and -2) of the rat cytochrome P-450IA1 gene and a constitutive, nuclear XRE-binding factor that is distinct from the dioxin receptor.

Dioxin stimulates transcription from the cytochrome P-450IA1 promoter by interaction with the intracellular dioxin receptor. Upon binding of ligand, the receptor is converted to a form which specifically interacts in vitro with two dioxin-responsive positive control elements located in close proximi...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Hapgood, J, Cuthill, S, Söderkvist, P, Wilhelmsson, A, Pongratz, I, Tukey, R H, Johnson, E F, Gustafsson, J A, Poellinger, L
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC361292/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1652054/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.11.9.4314-4323.1991
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