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Liver cells contain constitutive DNase I-hypersensitive sites at the xenobiotic response elements 1 and 2 (XRE1 and -2) of the rat cytochrome P-450IA1 gene and a constitutive, nuclear XRE-binding factor that is distinct from the dioxin receptor.

Dioxin stimulates transcription from the cytochrome P-450IA1 promoter by interaction with the intracellular dioxin receptor. Upon binding of ligand, the receptor is converted to a form which specifically interacts in vitro with two dioxin-responsive positive control elements located in close proximi...

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Udgivet i:Mol Cell Biol
Principais autores: Hapgood, J, Cuthill, S, Söderkvist, P, Wilhelmsson, A, Pongratz, I, Tukey, R H, Johnson, E F, Gustafsson, J A, Poellinger, L
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1991
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC361292/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1652054/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.11.9.4314-4323.1991
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