Liver cells contain constitutive DNase I-hypersensitive sites at the xenobiotic response elements 1 and 2 (XRE1 and -2) of the rat cytochrome P-450IA1 gene and a constitutive, nuclear XRE-binding factor that is distinct from the dioxin receptor.

Ítems similars

• Specific protein-DNA interactions at a xenobiotic-responsive element: copurification of dioxin receptor and DNA-binding activity.
  per: Hapgood, J, et al.
  Publicat: (1989)
• Ligand-dependent recruitment of the Arnt coregulator determines DNA recognition by the dioxin receptor.
  per: Whitelaw, M, et al.
  Publicat: (1993)
• Role of the ligand in intracellular receptor function: receptor affinity determines activation in vitro of the latent dioxin receptor to a DNA-binding form.
  per: Cuthill, S, et al.
  Publicat: (1991)
• Cross-coupling of signal transduction pathways: the dioxin receptor mediates induction of cytochrome P-450IA1 expression via a protein kinase C-dependent mechanism.
  per: Berghard, A, et al.
  Publicat: (1993)
• The specific DNA binding activity of the dioxin receptor is modulated by the 90 kd heat shock protein.
  per: Wilhelmsson, A, et al.
  Publicat: (1990)