PKCβ-induced Selective IRS1 Dysfunction and Insulin Resistance in Renal Glomeruli of Rodent Models of Diabetes and Obesity

Insulin resistance has been associated with the progression of chronic kidney disease in both diabetes and obesity. This study characterizes insulin signaling in renal tubules and glomeruli in insulin resistant and diabetic states. Insulin-induced phosphorylation of insulin receptor substrate-1 (IRS...

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Main Authors: Mima, Akira, Ohshiro, Yuzuru, Kitada, Munehiro, Matsumoto, Motonobu, Geraldes, Pedro, Li, Chenzhong, Li, Qian, White, Gregory, Cahill, Christopher, Rask-Madsen, Christian, King, George L.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2011
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3612886/
https://ncbi.nlm.nih.gov/pubmed/21228767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2010.526
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