Ikaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signaling

The transcription factor Ikaros regulates the development of hematopoietic cells. Ikaros-deficient animals fail to develop B cells and display a T-cell malignancy, which is correlated with altered Notch signaling. Recently, loss of Ikaros was associated with progression of myeloproliferative neoplas...

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Hlavní autoři: Malinge, Sébastien, Thiollier, Clarisse, Chlon, Timothy M., Doré, Louis C., Diebold, Lauren, Bluteau, Olivier, Mabialah, Vinciane, Vainchenker, William, Dessen, Philippe, Winandy, Susan, Mercher, Thomas, Crispino, John D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2013
Témata:
Hematopoiesis and Stem Cells
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3612856/
https://ncbi.nlm.nih.gov/pubmed/23335373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-08-450627
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