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Ikaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signaling
The transcription factor Ikaros regulates the development of hematopoietic cells. Ikaros-deficient animals fail to develop B cells and display a T-cell malignancy, which is correlated with altered Notch signaling. Recently, loss of Ikaros was associated with progression of myeloproliferative neoplas...
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| 主要な著者: | , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society of Hematology
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3612856/ https://ncbi.nlm.nih.gov/pubmed/23335373 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-08-450627 |
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