Overexpression of MRPS18-2 in Cancer Cell Lines Results in Appearance of Multinucleated Cells

Human mitochondrial ribosomal protein MRPS18-2 (S18-2) is encoded by a cellular gene that is located on the human chromosome 6p21.3. We discovered that overexpression of the S18-2 protein led to immortalization and de-differentiation of primary rat embryonic fibroblasts. Cells showed anchorage-indep...

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Main Authors: Shevchuk, Z., Yurchenko, M. Y., Darekar, S. D., Holodnuka-Kholodnyuk, I., Kashuba, V. I., Kashuba, E. V.
Formato: Artigo
Idioma:Inglês
Publicado: A.I. Gordeyev 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3612828/
https://ncbi.nlm.nih.gov/pubmed/23556133
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