Prediction of free imatinib concentrations based on total plasma concentrations in patients with gastrointestinal stromal tumours

AIM: Total imatinib concentrations are currently measured for the therapeutic drug monitoring of imatinib, whereas only free drug equilibrates with cells for pharmacological action. Due to technical and cost limitations, routine measurement of free concentrations is generally not performed. In this...

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Detalhes bibliográficos
Main Authors: Haouala, Amina, Widmer, Nicolas, Guidi, Monia, Montemurro, Michael, Leyvraz, Serge, Buclin, Thierry, Eap, Chin B, Decosterd, Laurent A, Csajka, Chantal
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2013
Assuntos:
Pharmacokinetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3612719/
https://ncbi.nlm.nih.gov/pubmed/22891806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2012.04422.x
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