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Role of ELOVL4 and very long-chain polyunsaturated fatty acids in mouse models of Stargardt type 3 retinal degeneration

Stargardt type 3 (STGD3) disease is a juvenile macular dystrophy caused by mutations in the ELOVL4 (Elongation of very long chain fatty acids 4) gene. Its protein product, ELOVL4, is an elongase required for the biosynthesis of very long-chain polyunsaturated fatty acids (VLC-PUFAs). It is unclear w...

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Bibliographic Details
Main Authors: Barabas, Peter, Liu, Aihua, Xing, Wei, Chen, Ching-Kang, Tong, Zongzhong, Watt, Carl B., Jones, Bryan W., Bernstein, Paul S., Križaj, David
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3612655/
https://ncbi.nlm.nih.gov/pubmed/23479632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1214707110
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