Tyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction.

A phosphatidylinositol-3 (PI-3) kinase activity of unknown biological function associates with tyrosine kinase-containing proteins, including a number of growth factor receptors after ligand stimulation. In the beta platelet-derived growth factor (beta PDGF) receptor, phosphorylation of a specific t...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Yu, J C, Heidaran, M A, Pierce, J H, Gutkind, J S, Lombardi, D, Ruggiero, M, Aaronson, S A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC361148/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1646396/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.11.7.3780-3785.1991
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