Depletion of c-myc with specific antisense sequences reverses the transformed phenotype in ras oncogene-transformed NIH 3T3 cells.

ras oncogene-transformed NIH 3T3 cells expressing glucocorticoid-inducible antisense c-myc cDNA transcripts at levels sufficient to deplete c-myc protein lost their transformed morphology and the ability to grow in soft agar; their ability to form tumors in nude mice was also impaired. These changes...

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Autori principali: Sklar, M D, Thompson, E, Welsh, M J, Liebert, M, Harney, J, Grossman, H B, Smith, M, Prochownik, E V
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1991
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC361133/
https://ncbi.nlm.nih.gov/pubmed/2046673
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