Depletion of c-myc with specific antisense sequences reverses the transformed phenotype in ras oncogene-transformed NIH 3T3 cells.

ras oncogene-transformed NIH 3T3 cells expressing glucocorticoid-inducible antisense c-myc cDNA transcripts at levels sufficient to deplete c-myc protein lost their transformed morphology and the ability to grow in soft agar; their ability to form tumors in nude mice was also impaired. These changes...

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Detalles Bibliográficos
Publicado en:Mol Cell Biol
Main Authors: Sklar, M D, Thompson, E, Welsh, M J, Liebert, M, Harney, J, Grossman, H B, Smith, M, Prochownik, E V
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 1991
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC361133/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2046673/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.11.7.3699
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