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A Pathophysiologic Role for Epidermal Growth Factor Receptor in Pemphigus Acantholysis

The pemphigus family of autoimmune bullous disorders is characterized by autoantibody binding to desmoglein 1 and/or 3 (dsg1/dsg3). In this study we show that EGF receptor (EGFR) is activated following pemphigus vulgaris (PV) IgG treatment of primary human keratinocytes and that EGFR activation is d...

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Auteurs principaux: Bektas, Meryem, Jolly, Puneet S., Berkowitz, Paula, Amagai, Masayuki, Rubenstein, David S.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2013
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3611014/
https://ncbi.nlm.nih.gov/pubmed/23404504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.438010
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