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EP2 Receptor Signaling Pathways Regulate Classical Activation of Microglia
Activation of EP2 receptors by prostaglandin E2 (PGE(2)) promotes brain inflammation in neurodegenerative diseases, but the pathways responsible are unclear. EP2 receptors couple to Gα(s) and increase cAMP, which associates with protein kinase A (PKA) and cAMP-regulated guanine nucleotide exchange f...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Biochemistry and Molecular Biology
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3611000/ https://ncbi.nlm.nih.gov/pubmed/23404506 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.455816 |
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