Chromatin Collapse during Caspase-dependent Apoptotic Cell Death Requires DNA Fragmentation Factor, 40-kDa Subunit-/Caspase-activated Deoxyribonuclease-mediated 3′-OH Single-strand DNA Breaks

Apoptotic nuclear morphology and oligonucleosomal double-strand DNA fragments (also known as DNA ladder) are considered the hallmarks of apoptotic cell death. From a classic point of view, these two processes occur concomitantly. Once activated, DNA fragmentation factor, 40-kDa subunit (DFF40)/caspa...

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Detalhes bibliográficos
Main Authors: Iglesias-Guimarais, Victoria, Gil-Guiñon, Estel, Sánchez-Osuna, María, Casanelles, Elisenda, García-Belinchón, Mercè, Comella, Joan X., Yuste, Victor J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3610992/
https://ncbi.nlm.nih.gov/pubmed/23430749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.411371
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