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Synergistic Activation of p21-activated Kinase 1 by Phosphatidylinositol 4,5-Bisphosphate and Rho GTPases
Autoinhibited p21-activated kinase 1 (Pak1) can be activated in vitro by the plasma membrane-bound Rho GTPases Rac1 and Cdc42 as well as by the lipid phosphatidylinositol (4,5)-bisphosphate (PIP(2)). Activator binding is mediated by a GTPase-binding motif and an adjacent phosphoinositide-binding mot...
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| Glavni autori: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2013
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3610963/ https://ncbi.nlm.nih.gov/pubmed/23393142 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.428904 |
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