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Ptch1 overexpression drives skin carcinogenesis and developmental defects in K14Ptch(FVB) mice
Ptch1 is a key regulator of embryonic development, acting through the sonic hedgehog (SHH) signaling pathway. Ptch1 is best known as a tumor suppressor, since germline or somatic mutations in Ptch1 lead to the formation of skin basal cell carcinomas (BCCs). Here, we show that Ptch1 also acts as a li...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3610826/ https://ncbi.nlm.nih.gov/pubmed/23223138 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2012.419 |
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